What is low dose Naltrexone?

Low dose naltrexone (LDN) is a one-tenth part of a regular naltrexone dose. It is an emerging treatment for many signs and symptoms of autoimmune and central nervous system disorders. Studies have also indicated its strong immuno-modulating and anti-inflammatory effects.

Basically, naltrexone is an imperative drug designed for opioid addicts that help diminish their addiction and prevent relapsing. Moreover, it also benefits drug addicts by providing a feeling of serenity, slower breathing, stopping pain, and as an anti-depressant. It was first approved for clinical use in 1984 by the food and drug administration (FDA), US.

Naltrexone acts as an antagonist of opioid receptors that proactively attaches them to block their activation. This prevents opioid receptors from producing effects that arise when they encounter an opioid found in analgesics (painkillers) and dangerous drugs like heroin.

How does it work for autoimmune diseases?

Low dose naltrexone opts for two main mechanisms of action to combat autoimmune conditions.

1. Block opioid receptors in the brain

LDN medication temporarily blocks the opioid receptors. When receptors are impeded, the body starts producing more opioids i.e., endorphins. Once LDN is out of the system, the opioid receptors are unblocked. However, it causes an overall increase in the production of natural opioids.

People suffering from different autoimmune disorders often have low opioid levels in the body. White blood cells, the major regulators of the immune system, possess opioid receptors that can be easily influenced by the low dose naltrexone effects. Therefore, LDN is an important tool for regulating immune system-related diseases.

2. Promote T regulatory cell function to regulate the immune system

Tregs or T regulatory cells are major regulators of immune responses. They maintain immune system balance and play a significant role in turning inflammation on and off depending on the requirements. Low dose naltrexone exerts regulatory effects on T regulatory cells and promotes their function. Therefore, it may help patients with an overactive immune system, asthma, allergies, and autoimmune conditions i.e., Hashimoto’s Thyroiditis. In addition, LDN helps maintain a healthy and balanced immune system without exerting any suppressing and narcotic effects.

Low dose naltrexone for chronic fatigue syndrome and fibromyalgia treatment

Low dose naltrexone (LDN) blocks opioid receptors and naturally increases endorphins, the feel-good molecule, that enhances pain tolerance and immune system function. Thus, if LDN is taken daily, it may trigger endorphin secretions and cause naturally elevated pain tolerance in the body. Therefore, low dose naltrexone may help in alleviating pain and fatigue linked with fibromyalgia and chronic fatigue syndrome. Besides blocking opioid receptors, low dose naltrexone impedes certain proteins that regulate the symptoms of chronic fatigue syndrome and fibromyalgia. Furthermore, low dose naltrexone (LDN) works as an anti-inflammatory drug by downregulating pro-inflammatory cytokines thus, reduces swelling and inflammation in the nervous system and helps relieve pain.  

Is it safe to use?

Studies have shown that low dose naltrexone side effects are rare. It is a cost-effective and safe treatment for autoimmunity and chronic pain. LDN naltrexone decreases inflammation that aids in pain reduction, and improves sleep, fatigue, mood, and physical function.